The E-STAND trial was made to formally test the use of epidural spinal cord stimulation for restoring volitional movement in the legs of patients who suffered spinal cord injury and have been unable to move either leg since injury. In addition, the trial was constructed to figure out how to choose stimulation settings that provide the largest improvement in movement.
The E-STAND trial is also hoping to begin to understand how epidural spinal cord stimulation in this patient population can affect blood pressure, heart function, urinary function, and some aspects of cognitive function.
In order for patients to participate they must meet the inclusion and exclusion criteria for the study. We have listed some of the main criteria below. After reading through the criteria below, you can sign up to be formally evaluated by our team through the link at the bottom and completing the short survey. If you’re not sure if you are eligible after reading the criteria, you can sign up below anyways so we can determine if you are eligible for the trial.
- 22 years of age or older
- Able to undergo the informed consent process
- Stable, motor-complete paraplegia
- Discrete spinal cord injury between C6 and T10
- ASIA A or B Spinal Cord Injury Classification
- Medically stable
- Intact segmental reflexes below the lesion of injury
- Greater than 1 year since initial injury and at least 6 months from any required spinal instrumentation
- Willing to attend all scheduled appointments
- Diseases and conditions that would increase the morbidity and mortality of spinal cord injury surgery (e.g. cardiopulmonary issues)
- Inability to withhold antiplatelet/anticoagulation agents perioperatively
- Significant dysautonomia
- Botulinum toxin injections in the previous 6 months
- Volitional movements present during EMG testing in bilateral lower extremities
- Unhealed spinal fracture
- Presence of significant contracture
- Presence of pressure ulcers
- Recurrent urinary tract infection refractory to antibiotics
- Current Pregnancy
Take the prescreen survey here.